1. Round | 13/03/2022 | San Antonio FC | - | Detroit City FC | 1:0 | ||||
1. Round | 19/03/2022 | Los Angeles Galaxy II | - | San Antonio FC | 1:2 | ||||
1. Round | 28/03/2022 | Rio Grande Valley FC | - | San Antonio FC | 1:2 | ||||
2. Round | 03/04/2022 | San Antonio FC | - | Phoenix Rising | 0:2 | ||||
3. Round | 08/05/2022 | Phoenix Rising | - | San Antonio FC | 3:0 | ||||
3. Round | 29/05/2022 | Rio Grande Valley FC | - | San Antonio FC | 2:3 | ||||
4. Round | 05/06/2022 | Sacramento Republic | - | San Antonio FC | 1:0 | ||||
4. Round | 11/06/2022 | Monterey Bay FC | - | San Antonio FC | 2:3 | ||||
4. Round | 19/06/2022 | San Antonio FC | - | Oakland Roots | 1:1 | ||||
4. Round | 25/06/2022 | Colorado Springs Switchbacks | - | San Antonio FC | 0:1 | ||||
8. Round | 02/10/2022 | Pittsburgh Riverhounds | - | San Antonio FC | 0:1 | ||||
8. Round | 09/10/2022 | Birmingham Legion | - | San Antonio FC | 1:2 | ||||
8. Round | 16/10/2022 | San Antonio FC | - | Orange County SC | 2:2 |