8. Round | 12/09/2021 | Platense | - | Vida | 1:4 | ||||
9. Round | 16/09/2021 | Motagua | - | Vida | 2:1 | ||||
10. Round | 20/09/2021 | Vida | - | Honduras Progreso | 1:0 | ||||
11. Round | 25/09/2021 | Marathón | - | Vida | 1:2 | ||||
12. Round | 03/10/2021 | Vida | - | Real Sociedad | 2:1 | ||||
13. Round | 10/10/2021 | Lobos UPNFM | - | Vida | 0:0 | ||||
14. Round | 17/10/2021 | Vida | - | Olimpia | 2:1 | ||||
15. Round | 24/10/2021 | Victoria | - | Vida | 1:2 | ||||
16. Round | 28/10/2021 | Vida | - | Motagua | 1:1 | ||||
17. Round | 31/10/2021 | Vida | - | Platense | 3:1 | ||||
18. Round | 10/11/2021 | Real España | - | Vida | 2:1 |