1. Round | 13/09/2021 | Aris Saloniki | - | OFI Heraklion | 0:0 | ||||
2. Round | 19/09/2021 | OFI Heraklion | - | AEK Athen | 3:3 | ||||
3. Round | 22/09/2021 | OFI Heraklion | - | Asteras Tripolis | 0:0 | ||||
4. Round | 27/09/2021 | PAS Giannina | - | OFI Heraklion | 1:1 | ||||
5. Round | 03/10/2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 | ||||
6. Round | 17/10/2021 | Panetolikos | - | OFI Heraklion | 1:2 | ||||
7. Round | 24/10/2021 | OFI Heraklion | - | Lamia | 0:0 | ||||
8. Round | 31/10/2021 | Panathinaikos | - | OFI Heraklion | 0:0 | ||||
9. Round | 06/11/2021 | OFI Heraklion | - | Atromitos | 2:0 | ||||
11. Round | 28/11/2021 | OFI Heraklion | - | Ionikos Nikea | 2:1 | ||||
12. Round | 04/12/2021 | OFI Heraklion | - | Olympiakos Piraeus | 1:3 | ||||
14. Round | 16/12/2021 | OFI Heraklion | - | Aris Saloniki | 1:1 | ||||
15. Round | 20/12/2021 | AEK Athen | - | OFI Heraklion | 1:2 | ||||
23. Round | 13/02/2022 | OFI Heraklion | - | Volos NFC | 2:1 | ||||
22. Round | 16/02/2022 | Atromitos | - | OFI Heraklion | 2:2 | ||||
24. Round | 19/02/2022 | Ionikos Nikea | - | OFI Heraklion | 0:0 | ||||
25. Round | 27/02/2022 | Olympiakos Piraeus | - | OFI Heraklion | 2:0 | ||||
26. Round | 06/03/2022 | OFI Heraklion | - | Apollon Smyrnis | 2:0 |