1. Round | 24/07/2021 | Club Necaxa | - | Santos Laguna | 0:3 | ||||
2. Round | 01/08/2021 | CF América | - | Club Necaxa | 2:1 | ||||
3. Round | 07/08/2021 | Club Necaxa | - | Cruz Azul | 1:2 | ||||
4. Round | 13/08/2021 | Atlético San Luis | - | Club Necaxa | 0:2 | ||||
15. Round | 23/10/2021 | CF Monterrey | - | Club Necaxa | 0:1 | ||||
16. Round | 30/10/2021 | Club Necaxa | - | Mazatlán FC | 2:1 |