2. Round | 12/02/2022 | Libertad | - | General Caballero DJLM | 1:0 | ||||
3. Round | 19/02/2022 | General Caballero DJLM | - | Tacuary | 2:0 | ||||
4. Round | 25/02/2022 | Sportivo Ameliano | - | General Caballero DJLM | 1:0 | ||||
5. Round | 04/03/2022 | General Caballero DJLM | - | Club Nacional | 1:2 | ||||
6. Round | 12/03/2022 | Guaraní | - | General Caballero DJLM | 3:1 | ||||
7. Round | 21/03/2022 | General Caballero DJLM | - | Guaireña FC | 0:1 | ||||
8. Round | 03/04/2022 | Sol de América | - | General Caballero DJLM | 2:3 | ||||
9. Round | 09/04/2022 | General Caballero DJLM | - | Cerro Porteño | 0:0 | ||||
12. Round | 24/04/2022 | General Caballero DJLM | - | Club Olimpia | 2:3 | ||||
13. Round | 30/04/2022 | General Caballero DJLM | - | Libertad | 0:1 | ||||
14. Round | 07/05/2022 | Tacuary | - | General Caballero DJLM | 0:0 | ||||
15. Round | 10/05/2022 | General Caballero DJLM | - | Sportivo Ameliano | 0:3 | ||||
16. Round | 14/05/2022 | Club Nacional | - | General Caballero DJLM | 1:2 |