1. Round | 09/01/2021 | Puebla FC | - | Deportivo Guadalajara | 1:1 | ||||
2. Round | 17/01/2021 | Cruz Azul | - | Puebla FC | 0:1 | ||||
3. Round | 23/01/2021 | Puebla FC | - | Club Tijuana | 0:1 | ||||
4. Round | 03/02/2021 | Puebla FC | - | CF Monterrey | 0:0 | ||||
5. Round | 07/02/2021 | CF América | - | Puebla FC | 1:0 | ||||
6. Round | 13/02/2021 | Puebla FC | - | FC Juárez | 4:0 | ||||
7. Round | 21/02/2021 | Gallos Blancos | - | Puebla FC | 1:1 | ||||
8. Round | 27/02/2021 | Puebla FC | - | Club Necaxa | 1:0 | ||||
10. Round | 06/03/2021 | Puebla FC | - | UANL Tigres | 1:1 | ||||
12. Round | 21/03/2021 | Deportivo Toluca | - | Puebla FC | 4:4 | ||||
14. Round | 13/04/2021 | CF Pachuca | - | Puebla FC | 1:3 | ||||
17. Round | 03/05/2021 | Santos Laguna | - | Puebla FC | 0:0 |