1. Round | 13/09/2021 | Progreso | - | Villa Española | 1:1 | ||||
3. Round | 24/09/2021 | Plaza Colonia | - | Villa Española | 4:0 | ||||
6. Round | 17/10/2021 | Villa Española | - | Montevideo Wanderers | 2:2 | ||||
7. Round | 20/10/2021 | Rentistas | - | Villa Española | 3:1 | ||||
9. Round | 31/10/2021 | Montevideo City Torque | - | Villa Española | 5:0 | ||||
11. Round | 07/11/2021 | Villa Española | - | Nacional | 1:2 | ||||
12. Round | 13/11/2021 | Cerrito | - | Villa Española | 1:0 |