1. Round | 17/03/2021 | Atlético Porteño | - | Atlético Santo Domingo | 1:1 | ||||
2. Round | 25/03/2021 | Atlético Santo Domingo | - | América de Quito | 1:1 | ||||
3. Round | 01/04/2021 | Cumbayá | - | Atlético Santo Domingo | 2:1 | ||||
9. Round | 20/05/2021 | Atlético Santo Domingo | - | Liga de Portoviejo | 3:2 | ||||
13. Round | 09/06/2021 | Atlético Santo Domingo | - | Chacaritas FC | 3:0 | ||||
15. Round | 16/06/2021 | Atlético Santo Domingo | - | Guayaquil SC | 0:1 | ||||
17. Round | 23/06/2021 | Liga de Portoviejo | - | Atlético Santo Domingo | 2:0 | ||||
18. Round | 27/06/2021 | Atlético Santo Domingo | - | Atlético Porteño | 2:1 | ||||
19. Round | 03/07/2021 | Atlético Santo Domingo | - | Gualaceo SC | 1:4 |