1. Round | 24/07/2021 | CF Pachuca | - | Club León | 4:0 | ||||
3. Round | 06/08/2021 | Gallos Blancos | - | Club León | 0:1 | ||||
5. Round | 19/08/2021 | Deportivo Guadalajara | - | Club León | 0:3 | ||||
9. Round | 18/09/2021 | Club León | - | FC Juárez | 0:1 | ||||
13. Round | 16/10/2021 | CF Monterrey | - | Club León | 0:1 | ||||
15. Round | 23/10/2021 | Puebla FC | - | Club León | 0:1 | ||||
11. Round | 04/11/2021 | Cruz Azul | - | Club León | 0:1 | ||||
17. Round | 06/11/2021 | Club León | - | Club Necaxa | 3:0 |