10. Round | 06/03/2022 | Santa Fe | - | Millonarios | 0:3 | ||||
11. Round | 17/03/2022 | Deportivo Pasto | - | Santa Fe | 2:4 | ||||
12. Round | 22/03/2022 | Santa Fe | - | Atlético Bucaramanga | 3:1 | ||||
13. Round | 29/03/2022 | Atlético Nacional | - | Santa Fe | 2:1 | ||||
14. Round | 04/04/2022 | Santa Fe | - | Unión Magdalena | 1:0 | ||||
15. Round | 10/04/2022 | Envigado FC | - | Santa Fe | 1:0 | ||||
16. Round | 16/04/2022 | Santa Fe | - | Alianza Petrolera | 0:1 | ||||
17. Round | 25/04/2022 | Millonarios | - | Santa Fe | 2:1 | ||||
18. Round | 01/05/2022 | Santa Fe | - | Jaguares de Córdoba | 4:0 | ||||
19. Round | 07/05/2022 | Deportivo Cali | - | Santa Fe | 1:1 | ||||
20. Round | 15/05/2022 | Once Caldas | - | Santa Fe | 2:2 |