1. Round | 09/01/2021 | Puebla FC | - | Deportivo Guadalajara | 1:1 | ||||
2. Round | 16/01/2021 | Deportivo Guadalajara | - | Deportivo Toluca | 1:1 | ||||
3. Round | 22/01/2021 | Atlético San Luis | - | Deportivo Guadalajara | 3:1 | ||||
4. Round | 31/01/2021 | Deportivo Guadalajara | - | FC Juárez | 1:2 | ||||
5. Round | 09/02/2021 | Club León | - | Deportivo Guadalajara | 1:3 | ||||
8. Round | 01/03/2021 | Deportivo Guadalajara | - | Pumas UNAM | 2:1 | ||||
9. Round | 04/03/2021 | Gallos Blancos | - | Deportivo Guadalajara | 2:2 | ||||
10. Round | 07/03/2021 | Mazatlán FC | - | Deportivo Guadalajara | 1:1 | ||||
11. Round | 15/03/2021 | Deportivo Guadalajara | - | CF América | 0:3 | ||||
14. Round | 11/04/2021 | Cruz Azul | - | Deportivo Guadalajara | 1:0 | ||||
15. Round | 18/04/2021 | Deportivo Guadalajara | - | Club Tijuana | 2:0 | ||||
12. Round | 22/04/2021 | CF Monterrey | - | Deportivo Guadalajara | 1:2 | ||||
16. Round | 25/04/2021 | Atlas Guadalajara | - | Deportivo Guadalajara | 0:1 | ||||
17. Round | 01/05/2021 | Deportivo Guadalajara | - | UANL Tigres | 0:0 |