1. Round | 10/01/2022 | Deportivo Guadalajara | - | Mazatlán FC | 3:0 | ||||
2. Round | 16/01/2022 | CF Pachuca | - | Deportivo Guadalajara | 2:1 | ||||
3. Round | 22/01/2022 | Deportivo Guadalajara | - | Gallos Blancos | 1:1 | ||||
4. Round | 10/02/2022 | FC Juárez | - | Deportivo Guadalajara | 1:3 | ||||
7. Round | 27/02/2022 | Deportivo Guadalajara | - | Puebla FC | 2:3 | ||||
13. Round | 10/04/2022 | Deportivo Toluca | - | Deportivo Guadalajara | 1:1 | ||||
14. Round | 17/04/2022 | Cruz Azul | - | Deportivo Guadalajara | 0:1 | ||||
15. Round | 20/04/2022 | Deportivo Guadalajara | - | Club Tijuana | 2:1 | ||||
16. Round | 24/04/2022 | Deportivo Guadalajara | - | Pumas UNAM | 3:1 | ||||
17. Round | 30/04/2022 | Club Necaxa | - | Deportivo Guadalajara | 0:1 |