1. Round | 31/08/2016 | Boston River | - | Defensor Sporting | 1:1 | ||||
2. Round | 04/09/2016 | Defensor Sporting | - | Juventud de Las Piedras | 0:1 | ||||
5. Round | 24/09/2016 | Defensor Sporting | - | CA Cerro | 0:1 | ||||
6. Round | 02/10/2016 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
7. Round | 09/10/2016 | Fénix | - | Defensor Sporting | 3:1 | ||||
8. Round | 16/10/2016 | Defensor Sporting | - | Liverpool | 1:3 | ||||
10. Round | 29/10/2016 | Rampla Juniors | - | Defensor Sporting | 0:1 | ||||
11. Round | 12/11/2016 | Villa Española | - | Defensor Sporting | 2:2 |