1. Round | 18/09/2021 | Club Necaxa [] | - | Santos Laguna [] | 4:0 | ||||
3. Round | 02/10/2021 | Club Necaxa [] | - | Deportivo Guadalajara [] | 0:2 | ||||
5. Round | 16/10/2021 | Atlas Guadalajara [] | - | Club Necaxa [] | 1:2 | ||||
6. Round | 23/10/2021 | Club Necaxa [] | - | Atlético San Luis [] | 5:0 | ||||
9. Round | 13/11/2021 | Mazatlán FC [] | - | Club Necaxa [] | 1:3 | ||||
10. Round | 20/11/2021 | Club Necaxa [] | - | CF Monterrey [] | 1:1 |