1. Round | 07/02/2021 | Club Olimpia | - | Libertad | 0:1 | ||||
3. Round | 15/02/2021 | Libertad | - | Cerro Porteño | 2:1 | ||||
4. Round | 21/02/2021 | Club Nacional | - | Libertad | 0:3 | ||||
2. Round | 24/02/2021 | Guaireña FC | - | Libertad | 1:0 | ||||
5. Round | 01/03/2021 | Libertad | - | River Plate | 2:1 | ||||
6. Round | 05/03/2021 | 12 de Octubre de Itauguá | - | Libertad | 2:1 | ||||
10. Round | 04/04/2021 | Libertad | - | Club Olimpia | 0:1 | ||||
11. Round | 12/04/2021 | Libertad | - | Guaireña FC | 2:1 | ||||
17. Round | 22/05/2021 | Libertad | - | Sol de América | 1:2 |