Round of 16 | 17/02/2022 | Deportivo Saprissa | - | Pumas UNAM | 2:2 | ||||
Round of 16 | 24/02/2022 | Pumas UNAM | - | Deportivo Saprissa | 4:1 | ||||
Quarter-finals | 10/03/2022 | New England Revolution | - | Pumas UNAM | 3:0 | ||||
Semi-finals | 13/04/2022 | Cruz Azul | - | Pumas UNAM | 0:0 |