3. Round | 15/08/2021 | Lobos UPNFM | - | Honduras Progreso | 3:0 | ||||
4. Round | 22/08/2021 | Lobos UPNFM | - | Platense | 3:0 | ||||
5. Round | 26/08/2021 | Real España | - | Lobos UPNFM | 5:3 | ||||
6. Round | 31/08/2021 | Motagua | - | Lobos UPNFM | 0:0 | ||||
8. Round | 12/09/2021 | Lobos UPNFM | - | Olimpia | 0:0 | ||||
9. Round | 15/09/2021 | Lobos UPNFM | - | Real Sociedad | 2:0 | ||||
12. Round | 03/10/2021 | Lobos UPNFM | - | Marathón | 1:1 | ||||
14. Round | 17/10/2021 | Honduras Progreso | - | Lobos UPNFM | 0:1 | ||||
17. Round | 31/10/2021 | Olimpia | - | Lobos UPNFM | 2:1 | ||||
18. Round | 10/11/2021 | Victoria | - | Lobos UPNFM | 1:0 |