2. Round | 05/03/2021 | Santa Fe | - | Deportes Tolima | 3:2 | ||||
11. Round | 09/03/2021 | Santa Fe | - | Deportivo Pasto | 2:2 | ||||
13. Round | 20/03/2021 | Envigado FC | - | Santa Fe | 2:1 | ||||
14. Round | 24/03/2021 | Santa Fe | - | Once Caldas | 2:0 | ||||
15. Round | 27/03/2021 | Atlético Junior | - | Santa Fe | 1:1 | ||||
16. Round | 03/04/2021 | Santa Fe | - | Deportivo Pereira | 1:1 | ||||
17. Round | 07/04/2021 | Alianza Petrolera | - | Santa Fe | 0:3 | ||||
19. Round | 18/04/2021 | La Equidad | - | Santa Fe | 1:2 |