1. Round | 25/07/2021 | Deportivo Guadalajara | - | Atlético San Luis | 1:2 | ||||
3. Round | 07/08/2021 | Deportivo Guadalajara | - | FC Juárez | 2:2 | ||||
4. Round | 16/08/2021 | Santos Laguna | - | Deportivo Guadalajara | 0:0 | ||||
5. Round | 19/08/2021 | Deportivo Guadalajara | - | Club León | 0:3 | ||||
6. Round | 22/08/2021 | CF Monterrey | - | Deportivo Guadalajara | 0:0 | ||||
7. Round | 28/08/2021 | Deportivo Guadalajara | - | Club Necaxa | 2:1 | ![]() |
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8. Round | 12/09/2021 | Pumas UNAM | - | Deportivo Guadalajara | 0:0 | ||||
9. Round | 19/09/2021 | Deportivo Guadalajara | - | CF Pachuca | 1:0 | ||||
10. Round | 26/09/2021 | CF América | - | Deportivo Guadalajara | 0:0 | ||||
12. Round | 03/10/2021 | Deportivo Guadalajara | - | Atlas Guadalajara | 0:1 | ||||
15. Round | 24/10/2021 | Deportivo Guadalajara | - | Cruz Azul | 1:1 |