1. Round | 10/01/2022 | Deportivo Guadalajara | - | Mazatlán FC | 3:0 | ||||
2. Round | 16/01/2022 | CF Pachuca | - | Deportivo Guadalajara | 2:1 | ||||
5. Round | 12/02/2022 | Deportivo Guadalajara | - | UANL Tigres | 1:3 | ||||
13. Round | 10/04/2022 | Deportivo Toluca | - | Deportivo Guadalajara | 1:1 | ||||
14. Round | 17/04/2022 | Cruz Azul | - | Deportivo Guadalajara | 0:1 |