5. Round | 17/08/2021 | Santa Fe | - | La Equidad | 0:2 | ||||
6. Round | 21/08/2021 | Deportivo Pereira | - | Santa Fe | 1:1 | ||||
7. Round | 30/08/2021 | Santa Fe | - | América de Cali | 1:1 | ||||
8. Round | 05/09/2021 | Independiente Medellín | - | Santa Fe | 0:0 | ||||
17. Round | 02/11/2021 | Deportes Quindío | - | Santa Fe | 1:1 | ||||
18. Round | 07/11/2021 | Santa Fe | - | Atlético Junior | 1:1 |