1. Round | 14/02/2022 | Boca Juniors | - | Colón de Santa Fe | 1:1 | ||||
2. Round | 17/02/2022 | Colón de Santa Fe | - | Godoy Cruz | 3:1 | ||||
3. Round | 23/02/2022 | Central Córdoba SdE | - | Colón de Santa Fe | 0:2 | ||||
4. Round | 26/02/2022 | Colón de Santa Fe | - | Barracas Central | 2:1 | ||||
5. Round | 08/03/2022 | Tigre | - | Colón de Santa Fe | 1:0 | ||||
9. Round | 09/04/2022 | Rosario Central | - | Colón de Santa Fe | 2:2 | ||||
10. Round | 16/04/2022 | Colón de Santa Fe | - | Independiente | 2:2 | ||||
11. Round | 19/04/2022 | Huracán | - | Colón de Santa Fe | 1:1 | ||||
14. Round | 09/05/2022 | Colón de Santa Fe | - | Vélez Sarsfield | 1:2 |