1. Round | 08/01/2022 | Puebla FC | - | CF América | 1:1 | ||||
3. Round | 23/01/2022 | CF América | - | Atlas Guadalajara | 0:2 | ||||
4. Round | 06/02/2022 | CF América | - | Atlético San Luis | 2:3 | ||||
5. Round | 13/02/2022 | Santos Laguna | - | CF América | 2:3 | ||||
2. Round | 17/02/2022 | Mazatlán FC | - | CF América | 2:1 | ||||
7. Round | 27/02/2022 | Pumas UNAM | - | CF América | 0:0 | ||||
8. Round | 02/03/2022 | CF América | - | Gallos Blancos | 1:1 | ||||
9. Round | 06/03/2022 | CF Monterrey | - | CF América | 2:1 | ||||
10. Round | 13/03/2022 | Deportivo Guadalajara | - | CF América | 0:0 |