1. Round | 11/01/2022 | Pumas UNAM | - | Deportivo Toluca | 5:0 | ||||
2. Round | 15/01/2022 | Gallos Blancos | - | Pumas UNAM | 1:3 | ||||
4. Round | 06/02/2022 | Club Tijuana | - | Pumas UNAM | 1:0 | ||||
11. Round | 19/03/2022 | Pumas UNAM | - | Club Necaxa | 1:3 | ||||
9. Round | 26/03/2022 | Pumas UNAM | - | Mazatlán FC | 1:1 | ||||
13. Round | 09/04/2022 | Puebla FC | - | Pumas UNAM | 2:2 | ||||
15. Round | 21/04/2022 | Atlético San Luis | - | Pumas UNAM | 2:0 | ||||
16. Round | 24/04/2022 | Deportivo Guadalajara | - | Pumas UNAM | 3:1 | ||||
17. Round | 01/05/2022 | Pumas UNAM | - | CF Pachuca | 2:0 |