1. Round | 22/07/2012 | Santos Laguna | - | Club San Luis | 2:1 | ||||
2. Round | 29/07/2012 | Club San Luis | - | Cruz Azul | 1:2 | ||||
8. Round | 16/09/2012 | Pumas UNAM | - | Club San Luis | 0:1 | ||||
9. Round | 23/09/2012 | Club San Luis | - | CF Pachuca | 1:0 | ||||
10. Round | 30/09/2012 | UANL Tigres | - | Club San Luis | 0:0 | ||||
11. Round | 03/10/2012 | Club San Luis | - | CF América | 1:2 | ||||
12. Round | 07/10/2012 | Jaguares Chiapas | - | Club San Luis | 4:0 | ||||
13. Round | 14/10/2012 | Club San Luis | - | Atlante | 2:2 | ||||
14. Round | 21/10/2012 | Atlas Guadalajara | - | Club San Luis | 2:3 | ||||
15. Round | 27/10/2012 | Club San Luis | - | Gallos Blancos (old) | 0:0 | ||||
16. Round | 04/11/2012 | Club Tijuana | - | Club San Luis | 0:0 | ||||
17. Round | 11/11/2012 | Club San Luis | - | Deportivo Toluca | 0:2 |