1. Round | 10/01/2021 | UANL Tigres | - | Club León | 2:0 | ||||
2. Round | 19/01/2021 | Club León | - | CF Pachuca | 0:0 | ||||
4. Round | 02/02/2021 | Club León | - | Atlético San Luis | 3:1 | ||||
8. Round | 28/02/2021 | Club León | - | Cruz Azul | 0:1 | ||||
10. Round | 07/03/2021 | CF América | - | Club León | 2:1 | ||||
14. Round | 10/04/2021 | Atlas Guadalajara | - | Club León | 1:3 | ||||
16. Round | 24/04/2021 | Mazatlán FC | - | Club León | 4:3 | ||||
17. Round | 01/05/2021 | Club León | - | Gallos Blancos | 2:1 |