1. Round | 05/02/2022 | Resistencia SC | - | Tacuary | 1:0 | ||||
2. Round | 11/02/2022 | Tacuary | - | 12 de Octubre de Itauguá | 1:1 | ||||
3. Round | 19/02/2022 | General Caballero DJLM | - | Tacuary | 2:0 | ||||
5. Round | 06/03/2022 | Club Olimpia | - | Tacuary | 2:0 | ||||
6. Round | 11/03/2022 | Sportivo Ameliano | - | Tacuary | 0:2 | ||||
7. Round | 21/03/2022 | Tacuary | - | Club Nacional | 2:1 | ||||
8. Round | 04/04/2022 | Guaraní | - | Tacuary | 1:2 | ||||
9. Round | 11/04/2022 | Tacuary | - | Guaireña FC | 0:1 | ||||
10. Round | 19/04/2022 | Sol de América | - | Tacuary | 1:0 | ||||
11. Round | 21/04/2022 | Tacuary | - | Cerro Porteño | 2:0 | ||||
14. Round | 07/05/2022 | Tacuary | - | General Caballero DJLM | 0:0 | ||||
16. Round | 16/05/2022 | Tacuary | - | Club Olimpia | 1:4 | ||||
17. Round | 20/05/2022 | Tacuary | - | Sportivo Ameliano | 1:0 |