1. Round | 25/07/2021 | Deportivo Guadalajara | - | Atlético San Luis | 1:2 | ||||
2. Round | 31/07/2021 | Puebla FC | - | Deportivo Guadalajara | 0:2 | ||||
3. Round | 07/08/2021 | Deportivo Guadalajara | - | FC Juárez | 2:2 | ||||
4. Round | 16/08/2021 | Santos Laguna | - | Deportivo Guadalajara | 0:0 | ||||
5. Round | 19/08/2021 | Deportivo Guadalajara | - | Club León | 0:3 |