8. Round | 15/09/2021 | Leones Negros | - | Tapatío | 3:0 | ||||
9. Round | 22/09/2021 | Cancún FC | - | Leones Negros | 0:1 | ||||
10. Round | 01/10/2021 | Leones Negros | - | Atlético Morelia | 2:1 | ||||
11. Round | 07/10/2021 | Pumas Tabasco | - | Leones Negros | 1:1 | ||||
12. Round | 14/10/2021 | Leones Negros | - | Club Celaya | 1:2 | ||||
13. Round | 19/10/2021 | CF Monterrey II | - | Leones Negros | 0:1 | ||||
14. Round | 27/10/2021 | Leones Negros | - | Coyotes de Tlaxcala | 1:0 | ||||
15. Round | 04/11/2021 | Venados FC | - | Leones Negros | 0:1 | ||||
16. Round | 14/11/2021 | Leones Negros | - | Cimarrones de Sonora | 3:2 | ||||
17. Round | 18/11/2021 | Tepatitlán | - | Leones Negros | 2:1 |