13. Round | 04/08/2021 | Oriente Petrolero | - | San José | 4:0 | ||||
14. Round | 07/08/2021 | San José | - | The Strongest | 0:1 | ||||
15. Round | 15/08/2021 | Jorge Wilstermann | - | San José | 4:0 | ||||
16. Round | 18/08/2021 | Atlético Palmaflor | - | San José | 1:0 | ||||
17. Round | 21/08/2021 | San José | - | Always Ready | 0:4 | ||||
18. Round | 11/09/2021 | Royal Pari | - | San José | 6:1 | ||||
19. Round | 17/09/2021 | San José | - | Real Potosí | 0:0 | ||||
20. Round | 21/09/2021 | CD Guabirá | - | San José | 4:0 | ||||
21. Round | 25/09/2021 | San José | - | Blooming | 1:2 | ||||
22. Round | 20/10/2021 | Bolívar | - | San José | 4:1 | ||||
23. Round | 22/10/2021 | San José | - | Club Aurora | 1:4 | ||||
24. Round | 27/10/2021 | Real Tomayapo | - | San José | 1:0 | ||||
25. Round | 01/11/2021 | Independiente Petrolero | - | San José | 4:0 | ||||
29. Round | 05/12/2021 | The Strongest | - | San José | 2:0 |