2. Round | 14/03/2021 | Always Ready | - | San José | 5:0 | ||||
3. Round | 03/04/2021 | San José | - | Royal Pari | 0:3 | ||||
4. Round | 12/04/2021 | Real Potosí | - | San José | 3:0 | ||||
5. Round | 24/04/2021 | San José | - | CD Guabirá | 0:1 | ||||
6. Round | 04/05/2021 | Blooming | - | San José | 4:0 | ||||
7. Round | 08/05/2021 | San José | - | Bolívar | 0:5 | ||||
8. Round | 10/07/2021 | Club Aurora | - | San José | 3:0 | ||||
10. Round | 22/07/2021 | San José | - | Independiente Petrolero | 1:3 | ||||
11. Round | 26/07/2021 | Real Santa Cruz | - | San José | 5:0 | ||||
12. Round | 30/07/2021 | San José | - | Nacional Potosí | 0:4 | ||||
14. Round | 07/08/2021 | San José | - | The Strongest | 0:1 | ||||
15. Round | 15/08/2021 | Jorge Wilstermann | - | San José | 4:0 | ||||
16. Round | 18/08/2021 | Atlético Palmaflor | - | San José | 1:0 | ||||
17. Round | 21/08/2021 | San José | - | Always Ready | 0:4 | ||||
19. Round | 17/09/2021 | San José | - | Real Potosí | 0:0 | ||||
20. Round | 21/09/2021 | CD Guabirá | - | San José | 4:0 | ||||
24. Round | 27/10/2021 | Real Tomayapo | - | San José | 1:0 | ||||
26. Round | 22/11/2021 | San José | - | Real Santa Cruz | 1:2 | ||||
27. Round | 26/11/2021 | Nacional Potosí | - | San José | 7:1 |