1. Round | 29/07/2021 | CF Monterrey II | - | Cancún FC | 1:2 | ||||
3. Round | 11/08/2021 | Cancún FC | - | Correcaminos UAT | 0:1 | ||||
4. Round | 20/08/2021 | Atlante | - | Cancún FC | 1:0 | ||||
5. Round | 26/08/2021 | Cancún FC | - | Mineros de Zacatecas | 3:1 | ||||
6. Round | 03/09/2021 | Dorados de Sinaloa | - | Cancún FC | 2:0 | ||||
8. Round | 16/09/2021 | Tepatitlán | - | Cancún FC | 1:2 | ||||
9. Round | 22/09/2021 | Cancún FC | - | Leones Negros | 0:1 | ||||
12. Round | 14/10/2021 | Cancún FC | - | Atlético Morelia | 0:1 |