2. Round | 09/02/2021 | River Plate | - | Guaraní | 1:4 | ||||
3. Round | 15/02/2021 | Sol de América | - | River Plate | 1:1 | ||||
4. Round | 19/02/2021 | River Plate | - | Sportivo Luqueño | 1:0 | ||||
6. Round | 05/03/2021 | River Plate | - | Guaireña FC | 0:1 | ||||
7. Round | 09/03/2021 | Cerro Porteño | - | River Plate | 3:0 | ||||
8. Round | 13/03/2021 | River Plate | - | Club Nacional | 0:0 | ||||
9. Round | 21/03/2021 | Club Olimpia | - | River Plate | 5:1 | ||||
10. Round | 01/04/2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 | ||||
14. Round | 04/05/2021 | River Plate | - | Libertad | 1:3 | ||||
15. Round | 10/05/2021 | Guaireña FC | - | River Plate | 0:0 | ||||
16. Round | 16/05/2021 | River Plate | - | Cerro Porteño | 1:1 | ||||
17. Round | 24/05/2021 | Club Nacional | - | River Plate | 0:1 |