1. Round | 08/08/2021 | Motagua | - | Platense | 3:0 | ||||
2. Round | 13/08/2021 | Platense | - | Honduras Progreso | 1:1 | ||||
3. Round | 15/08/2021 | Platense | - | Real España | 0:2 | ||||
4. Round | 22/08/2021 | Lobos UPNFM | - | Platense | 3:0 | ||||
5. Round | 27/08/2021 | Platense | - | Marathón | 3:1 | ||||
8. Round | 12/09/2021 | Platense | - | Vida | 1:4 | ||||
9. Round | 16/09/2021 | Victoria | - | Platense | 2:0 | ||||
10. Round | 19/09/2021 | Platense | - | Real Sociedad | 2:3 | ||||
11. Round | 26/09/2021 | Platense | - | Lobos UPNFM | 2:3 | ||||
13. Round | 10/10/2021 | Platense | - | Motagua | 2:3 | ||||
14. Round | 17/10/2021 | Real España | - | Platense | 2:1 | ||||
15. Round | 24/10/2021 | Marathón | - | Platense | 1:1 | ||||
16. Round | 28/10/2021 | Platense | - | Victoria | 1:2 | ||||
17. Round | 31/10/2021 | Vida | - | Platense | 3:1 |