1. Round | 18/07/2021 | Club Olimpia | - | River Plate | 1:3 | ||||
5. Round | 14/08/2021 | River Plate | - | Club Nacional | 1:0 | ||||
8. Round | 11/09/2021 | Sportivo Luqueño | - | River Plate | 0:2 | ||||
10. Round | 26/09/2021 | River Plate | - | Club Olimpia | 1:2 | ||||
14. Round | 29/10/2021 | Club Nacional | - | River Plate | 1:1 | ||||
15. Round | 05/11/2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 |