1. Round | 08/01/2022 | Puebla FC | - | CF América | 1:1 | ||||
4. Round | 06/02/2022 | CF América | - | Atlético San Luis | 2:3 | ||||
5. Round | 13/02/2022 | Santos Laguna | - | CF América | 2:3 | ||||
2. Round | 17/02/2022 | Mazatlán FC | - | CF América | 2:1 | ||||
6. Round | 20/02/2022 | CF América | - | CF Pachuca | 1:3 | ||||
9. Round | 06/03/2022 | CF Monterrey | - | CF América | 2:1 | ||||
11. Round | 20/03/2022 | CF América | - | Deportivo Toluca | 3:0 | ||||
12. Round | 03/04/2022 | Club Necaxa | - | CF América | 0:1 | ||||
13. Round | 10/04/2022 | CF América | - | FC Juárez | 3:0 |