1. Round | 17/03/2021 | Atlético Porteño | - | Atlético Santo Domingo | 1:1 | ||||
2. Round | 25/03/2021 | Atlético Santo Domingo | - | América de Quito | 1:1 | ||||
3. Round | 01/04/2021 | Cumbayá | - | Atlético Santo Domingo | 2:1 | ||||
4. Round | 06/04/2021 | Atlético Santo Domingo | - | Independiente Juniors | 1:1 | ||||
5. Round | 14/04/2021 | Chacaritas FC | - | Atlético Santo Domingo | 1:0 | ||||
6. Round | 21/04/2021 | Atlético Santo Domingo | - | Gualaceo SC | 1:0 | ||||
7. Round | 05/05/2021 | Guayaquil SC | - | Atlético Santo Domingo | 0:1 |