2. Round | 10/04/2022 | Loudoun United | - | Louisville City FC | 0:2 | ||||
2. Round | 17/04/2022 | San Diego Loyal | - | Louisville City FC | 2:5 | ||||
2. Round | 23/04/2022 | Charleston Battery | - | Louisville City FC | 1:1 | ||||
3. Round | 01/05/2022 | Louisville City FC | - | Pittsburgh Riverhounds | 2:0 | ||||
3. Round | 05/05/2022 | Atlanta United II | - | Louisville City FC | 0:4 | ||||
3. Round | 14/05/2022 | Los Angeles Galaxy II | - | Louisville City FC | 4:3 | ||||
3. Round | 22/05/2022 | Louisville City FC | - | Monterey Bay FC | 0:2 | ||||
4. Round | 06/06/2022 | Tampa Bay Rowdies | - | Louisville City FC | 1:0 | ||||
4. Round | 19/06/2022 | Louisville City FC | - | Orange County SC | 3:1 | ||||
4. Round | 25/06/2022 | Hartford Athletic | - | Louisville City FC | 0:2 | ||||
5. Round | 03/07/2022 | Louisville City FC | - | Birmingham Legion | 2:1 | ||||
5. Round | 10/07/2022 | Louisville City FC | - | New York RB II | 6:0 | ||||
5. Round | 17/07/2022 | Memphis 901 | - | Louisville City FC | 1:2 | ||||
5. Round | 21/07/2022 | Louisville City FC | - | Phoenix Rising | 0:0 | ||||
5. Round | 31/07/2022 | El Paso Locomotive | - | Louisville City FC | 0:1 | ||||
6. Round | 07/08/2022 | Louisville City FC | - | Charleston Battery | 4:1 |