4. Round | 06/04/2021 | Atlético Porteño | - | Chacaritas FC | 1:3 | ||||
5. Round | 14/04/2021 | Liga de Portoviejo | - | Atlético Porteño | 1:2 | ||||
6. Round | 21/04/2021 | Atlético Porteño | - | Guayaquil SC | 3:4 | ||||
7. Round | 05/05/2021 | Cumbayá | - | Atlético Porteño | 2:1 | ||||
8. Round | 14/05/2021 | Atlético Porteño | - | Independiente Juniors | 1:4 |