1. Round | 12/03/2022 | Loudoun United | - | Indy Eleven | 1:0 | ||||
1. Round | 19/03/2022 | Tampa Bay Rowdies | - | Indy Eleven | 2:0 | ||||
2. Round | 03/04/2022 | Indy Eleven | - | Los Angeles Galaxy II | 1:1 | ||||
2. Round | 10/04/2022 | Rio Grande Valley FC | - | Indy Eleven | 1:2 | ||||
2. Round | 17/04/2022 | Indy Eleven | - | Atlanta United II | 2:1 | ||||
2. Round | 24/04/2022 | Indy Eleven | - | Orange County SC | 3:1 | ||||
3. Round | 01/05/2022 | Indy Eleven | - | Hartford Athletic | 1:0 | ||||
3. Round | 15/05/2022 | Memphis 901 | - | Indy Eleven | 2:1 | ||||
3. Round | 22/05/2022 | Indy Eleven | - | New York RB II | 2:0 | ||||
3. Round | 28/05/2022 | Indy Eleven | - | New Mexico United | 1:2 | ||||
4. Round | 19/06/2022 | Colorado Springs Switchbacks | - | Indy Eleven | 4:3 | ||||
4. Round | 26/06/2022 | San Diego Loyal | - | Indy Eleven | 5:0 |