Round of 16 | 24/02/2022 | Pumas UNAM | - | Deportivo Saprissa | 4:1 | ||||
Quarter-finals | 10/03/2022 | New England Revolution | - | Pumas UNAM | 3:0 | ||||
Quarter-finals | 17/03/2022 | Pumas UNAM | - | New England Revolution | 3:0 pso | ||||
Semi-finals | 06/04/2022 | Pumas UNAM | - | Cruz Azul | 2:1 |