1. Round | 25/07/2021 | Deportivo Guadalajara | - | Atlético San Luis | 1:2 | ||||
9. Round | 19/09/2021 | Deportivo Guadalajara | - | CF Pachuca | 1:0 | ||||
10. Round | 26/09/2021 | CF América | - | Deportivo Guadalajara | 0:0 | ||||
13. Round | 17/10/2021 | Deportivo Guadalajara | - | Deportivo Toluca | 2:0 | ||||
14. Round | 21/10/2021 | Club Tijuana | - | Deportivo Guadalajara | 0:0 |