1. Round | 16/07/2021 | Sepsi OSK | - | Academica Clinceni | 2:0 | ||||
2. Round | 26/07/2021 | Chindia Târgoviște | - | Sepsi OSK | 1:1 | ||||
3. Round | 02/08/2021 | Sepsi OSK | - | CS Mioveni | 1:2 | ||||
5. Round | 15/08/2021 | Sepsi OSK | - | Argeș Pitești | 0:2 | ||||
6. Round | 23/08/2021 | FCSB | - | Sepsi OSK | 1:1 | ||||
7. Round | 29/08/2021 | Sepsi OSK | - | FC Botoşani | 1:1 | ||||
8. Round | 13/09/2021 | CS Universitatea Craiova | - | Sepsi OSK | 1:1 | ||||
9. Round | 19/09/2021 | Sepsi OSK | - | UTA Arad | 0:0 | ||||
10. Round | 27/09/2021 | Gaz Metan Mediaş | - | Sepsi OSK | 0:0 | ||||
11. Round | 02/10/2021 | Sepsi OSK | - | Rapid Bucureşti | 2:2 | ||||
12. Round | 16/10/2021 | Sepsi OSK | - | FC Voluntari | 1:2 | ||||
13. Round | 25/10/2021 | CFR Cluj | - | Sepsi OSK | 2:0 | ||||
15. Round | 06/11/2021 | FC Universitatea Craiova | - | Sepsi OSK | 1:1 |