1. Round | 13/08/2021 | Gudja United | - | Sirens FC | 0:1 | ||||
2. Round | 22/08/2021 | Hibernians FC | - | Gudja United | 2:1 | ||||
3. Round | 12/09/2021 | Gudja United | - | St. Luċija FC | 2:2 | ||||
4. Round | 19/09/2021 | Sliema Wanderers | - | Gudja United | 2:3 | ||||
5. Round | 25/09/2021 | Gudja United | - | Valletta FC | 2:0 | ||||
6. Round | 16/10/2021 | Birkirkara FC | - | Gudja United | 2:0 | ||||
7. Round | 23/10/2021 | Gudja United | - | Hamrun Spartans | 1:3 | ||||
8. Round | 31/10/2021 | Balzan FC | - | Gudja United | 1:0 | ||||
9. Round | 20/11/2021 | Gudja United | - | Floriana FC | 0:1 | ||||
10. Round | 28/11/2021 | Gżira United | - | Gudja United | 3:2 | ||||
11. Round | 04/12/2021 | Mosta FC | - | Gudja United | 0:3 | ||||
12. Round | 13/12/2021 | Sirens FC | - | Gudja United | 0:0 | ||||
13. Round | 19/12/2021 | Gudja United | - | Hibernians FC | 1:2 | ||||
14. Round | 19/01/2022 | St. Luċija FC | - | Gudja United | 0:3 | ||||
15. Round | 22/01/2022 | Gudja United | - | Sliema Wanderers | 1:0 | ||||
19. Round | 19/02/2022 | Gudja United | - | Balzan FC | 1:0 | ||||
20. Round | 26/02/2022 | Floriana FC | - | Gudja United | 2:0 | ||||
21. Round | 05/03/2022 | Gudja United | - | Gżira United | 1:2 | ||||
22. Round | 12/03/2022 | Gudja United | - | Mosta FC | 1:0 |