1. Round | 25/07/2010 | Atlante | - | Santos Laguna | 1:4 | ||||
2. Round | 01/08/2010 | Santos Laguna | - | Pumas UNAM | 4:0 | ||||
4. Round | 15/08/2010 | Santos Laguna | - | Jaguares Chiapas | 1:0 | ||||
6. Round | 29/08/2010 | Santos Laguna | - | Atlas Guadalajara | 3:1 | ||||
8. Round | 19/09/2010 | Santos Laguna | - | Club Necaxa | 2:1 | ||||
9. Round | 26/09/2010 | CF América | - | Santos Laguna | 3:2 | ||||
11. Round | 10/10/2010 | Monarcas Morelia | - | Santos Laguna | 0:0 | ||||
12. Round | 16/10/2010 | Cruz Azul | - | Santos Laguna | 3:0 | ||||
13. Round | 24/10/2010 | Santos Laguna | - | CF Monterrey | 1:2 | ||||
16. Round | 06/11/2010 | Club San Luis | - | Santos Laguna | 1:1 |