1. Round | 08/01/2022 | Club Tijuana [] | - | Club León [] | 3:2 | ||||
2. Round | 15/01/2022 | Club León [] | - | UANL Tigres [] | 1:3 | ||||
3. Round | 22/01/2022 | Deportivo Guadalajara [] | - | Club León [] | 4:0 | ||||
6. Round | 12/02/2022 | Club León [] | - | Atlético San Luis [] | 1:0 | ||||
9. Round | 05/03/2022 | Club León [] | - | Mazatlán FC [] | 1:1 | ||||
14. Round | 06/04/2022 | Club León [] | - | Atlas Guadalajara [] | 1:0 |