1. Round 13/09/2020 CD Alavés - Real Betis 0:1
2. Round 20/09/2020 Real Betis - Real Valladolid 2:0
3. Round 26/09/2020 Real Betis - Real Madrid 2:3 yellow card
4. Round 29/09/2020 Getafe CF - Real Betis 3:0
5. Round 03/10/2020 Valencia CF - Real Betis 0:2 Goal yellow card
6. Round 18/10/2020 Real Betis - Real Sociedad 0:3
7. Round 24/10/2020 Atlético Madrid - Real Betis 2:0
8. Round 01/11/2020 Real Betis - Elche CF 3:1
9. Round 07/11/2020 FC Barcelona - Real Betis 5:2
16. Round 29/12/2020 Levante UD - Real Betis 4:3 GoalGoal
17. Round 02/01/2021 Real Betis - Sevilla FC 1:1 Goal
18. Round 11/01/2021 SD Huesca - Real Betis 0:2
19. Round 20/01/2021 Real Betis - RC Celta 2:1 GoalGoal
20. Round 23/01/2021 Real Sociedad - Real Betis 2:2 Goal
21. Round 01/02/2021 Real Betis - CA Osasuna 1:0
22. Round 07/02/2021 Real Betis - FC Barcelona 2:3
23. Round 14/02/2021 Villarreal CF - Real Betis 1:2
24. Round 19/02/2021 Real Betis - Getafe CF 1:0 yellow card
25. Round 28/02/2021 Cádiz CF - Real Betis 0:1
26. Round 08/03/2021 Real Betis - CD Alavés 3:2
27. Round 14/03/2021 Sevilla FC - Real Betis 1:0 yellow card
28. Round 19/03/2021 Real Betis - Levante UD 2:0
29. Round 04/04/2021 Elche CF - Real Betis 1:1
30. Round 11/04/2021 Real Betis - Atlético Madrid 1:1
33. Round 18/04/2021 Real Betis - Valencia CF 2:2 Goal
31. Round 21/04/2021 Real Betis - Athletic Bilbao 0:0
32. Round 24/04/2021 Real Madrid - Real Betis 0:0
34. Round 02/05/2021 Real Valladolid - Real Betis 1:1
35. Round 10/05/2021 Real Betis - Granada CF 2:1
36. Round 13/05/2021 SD Eibar - Real Betis 1:1
37. Round 16/05/2021 Real Betis - SD Huesca 1:0