1. Round | 08/08/2021 | Honduras Progreso | - | Marathón | 1:2 | ||||
2. Round | 11/08/2021 | Marathón | - | Lobos UPNFM | 5:1 | ||||
3. Round | 14/08/2021 | Marathón | - | Motagua | 2:0 | ||||
4. Round | 22/08/2021 | Vida | - | Marathón | 2:0 | ||||
5. Round | 27/08/2021 | Platense | - | Marathón | 3:1 | ||||
8. Round | 12/09/2021 | Victoria | - | Marathón | 1:0 | ||||
9. Round | 15/09/2021 | Marathón | - | Olimpia | 3:1 | ||||
10. Round | 20/09/2021 | Real España | - | Marathón | 0:1 | ||||
11. Round | 25/09/2021 | Marathón | - | Vida | 1:2 | ||||
14. Round | 17/10/2021 | Motagua | - | Marathón | 2:1 | ||||
18. Round | 10/11/2021 | Real Sociedad | - | Marathón | 0:3 |