1. Round | 14/08/2021 | HNK Cibalia | - | NK Opatija | 2:2 | ||||
2. Round | 21/08/2021 | NK Opatija | - | NK Inter Zaprešić | 3:0 | ||||
3. Round | 28/08/2021 | NK Kustošija | - | NK Opatija | 0:0 | ||||
4. Round | 10/09/2021 | NK Opatija | - | NK BSK Bijelo Brdo | 0:0 | ||||
5. Round | 15/09/2021 | Dinamo Zagreb II | - | NK Opatija | 2:1 | ||||
6. Round | 18/09/2021 | NK Opatija | - | NK Solin | 1:1 | ||||
8. Round | 02/10/2021 | NK Osijek II | - | NK Opatija | 0:2 | ||||
9. Round | 16/10/2021 | NK Opatija | - | NK Varaždin | 2:2 | ||||
10. Round | 23/10/2021 | NK Rudeš | - | NK Opatija | 3:0 | ||||
13. Round | 20/11/2021 | NK Opatija | - | NK Dugopolje | 0:2 | ||||
15. Round | 04/12/2021 | NK Opatija | - | HNK Orijent Rijeka | 0:1 |