1. Round | 18/03/2021 | Liga de Portoviejo | - | Guayaquil SC | 1:3 | ||||
2. Round | 24/03/2021 | Guayaquil SC | - | Cumbayá | 0:1 | ||||
3. Round | 30/03/2021 | Independiente Juniors | - | Guayaquil SC | 2:3 | ||||
4. Round | 07/04/2021 | Gualaceo SC | - | Guayaquil SC | 2:0 | ||||
5. Round | 15/04/2021 | Guayaquil SC | - | El Nacional | 2:1 | ||||
6. Round | 21/04/2021 | Atlético Porteño | - | Guayaquil SC | 3:4 | ||||
9. Round | 19/05/2021 | Guayaquil SC | - | Chacaritas FC | 0:0 | ||||
13. Round | 11/06/2021 | El Nacional | - | Guayaquil SC | 2:0 | ||||
14. Round | 13/06/2021 | Guayaquil SC | - | Atlético Porteño | 1:0 | ||||
15. Round | 16/06/2021 | Atlético Santo Domingo | - | Guayaquil SC | 0:1 | ||||
16. Round | 20/06/2021 | Guayaquil SC | - | América de Quito | 0:2 | ||||
17. Round | 23/06/2021 | Chacaritas FC | - | Guayaquil SC | 2:3 | ||||
18. Round | 27/06/2021 | Guayaquil SC | - | Liga de Portoviejo | 2:1 | ||||
19. Round | 04/07/2021 | Atlético Porteño | - | Guayaquil SC | 4:1 | ||||
20. Round | 08/07/2021 | Guayaquil SC | - | El Nacional | 3:1 | ||||
22. Round | 16/07/2021 | Independiente Juniors | - | Guayaquil SC | 1:2 | ||||
23. Round | 18/07/2021 | Guayaquil SC | - | Cumbayá | 1:2 | ||||
29. Round | 26/08/2021 | Guayaquil SC | - | Gualaceo SC | 0:2 |